Thrombophilia

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Hereditary thrombophilia

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors. Since the...

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Thrombophilia Screening.

Although controversial, screening for thrombophilia has become common. Testing for antiphospholipid antibodies is indicated in order to guide treatment decisions if there is clinical suspicion for antiphospholipid syndrome. The utility of identifying other thrombophilias in symptomatic venous thromboembolism (VTE) is questionable, as the risk of recurrence does not appear to be increased by an ...

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Thrombophilia and pulmonary endarterectomy.

UNLABELLED In the present study, we compared groups of patients with and without thrombophilia, who underwent pulmonary endarterectomy (PEA), definitive treatment for chronic pulmonary hypertension resulting from thromboembolic disease. METHODS AND PATIENTS Between September 2004 and June 2007, we operated 54 patients with CTEPH. We divided our patients into three groups. Group I patients, ha...

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Inherited thrombophilia: Part 2.

From the 'Charing Cross and Westminster Medical School, London, UK; 1RCCS Maggiore Hospital, Milan, Italy; Beth Israel Hospital, Boston USA; Universitv Hospital Leiden, The Netherlands; Research Centre of Medical Genetics, Moscow, The Russian Federation; WHO, Switzerland; Christian Medical College Hospital, Vellore, India; University of Lund, Malmö, Sweden; 'Institute of Clinical Genetics, Mosc...

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Mechanisms of thrombophilia

The term thrombophilia describes the predisposition to venous thromboembolism and, under certain circumstances, also an increased risk of arterial thrombosis. In a broad sense, thrombophilia includes any inherited or acquired disorder associated with an increased tendency to thrombosis. It was soon realised that thrombotic events have a complex multifactorial cause, usually a combination of gen...

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ژورنال

عنوان ژورنال: Practical Neurology

سال: 2002

ISSN: 1474-7758,1474-7766

DOI: 10.1046/j.1474-7766.2002.05064.x